LymphedemaV1, France, Analysis, bibRecord, 000340

MYC High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema

Identifieur interne : 000340 ( France/Analysis ); précédent : 000339; suivant : 000341

MYC High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema

Auteurs : Johanna Manner [Allemagne] ; Bernhard Radlwimmer [Allemagne] ; Peter Hohenberger [Allemagne] ; Katharina Mössinger [Allemagne] ; Stefan Küffer [Allemagne] ; Christian Sauer [Allemagne] ; Djeda Belharazem [Allemagne] ; Andreas Zettl [Suisse] ; Jean-Michel Coindre [France] ; Christian Hallermann [Allemagne] ; Jörg Thomas Hartmann [Allemagne] ; Detlef Katenkamp [Allemagne] ; Kathrin Katenkamp [Allemagne] ; Patrick Schöffski [Belgique] ; Raf Sciot [Belgique] ; Agnieszka Wozniak [Belgique] ; Peter Lichter [Allemagne] ; Alexander Marx [Allemagne] ; Philipp Ströbel [Allemagne]

Source :

The American Journal of Pathology [ 0002-9440 ] ; 2010.

RBID : PMC:2797867

Descripteurs français

KwdFr :
- Adulte, Adulte d'âge moyen, Amplification de gène (génétique), Délétion de segment de chromosome, Femelle, Homozygote, Humains, Hémangiosarcome (génétique), Hémangiosarcome (étiologie), Locus génétiques (génétique), Lymphoedème (), Lymphoedème (génétique), Maladie chronique, Mâle, Protéines proto-oncogènes c-myc (génétique), Radiothérapie (effets indésirables), Sujet âgé, Sujet âgé de 80 ans ou plus, Technique FISH, Variations de nombre de copies de segment d'ADN (génétique).
MESH :
- effets indésirables : Radiothérapie.
- génétique : Amplification de gène, Hémangiosarcome, Locus génétiques, Lymphoedème, Protéines proto-oncogènes c-myc, Variations de nombre de copies de segment d'ADN.
- étiologie : Hémangiosarcome.
- Adulte, Adulte d'âge moyen, Délétion de segment de chromosome, Femelle, Homozygote, Humains, Lymphoedème, Maladie chronique, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Technique FISH.

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Chromosome Deletion, Chronic Disease, DNA Copy Number Variations (genetics), Female, Gene Amplification (genetics), Genetic Loci (genetics), Hemangiosarcoma (etiology), Hemangiosarcoma (genetics), Homozygote, Humans, In Situ Hybridization, Fluorescence, Lymphedema (complications), Lymphedema (genetics), Male, Middle Aged, Proto-Oncogene Proteins c-myc (genetics), Radiotherapy (adverse effects).
MESH :
- chemical , genetics : Proto-Oncogene Proteins c-myc.
- adverse effects : Radiotherapy.
- complications : Lymphedema.
- etiology : Hemangiosarcoma.
- genetics : DNA Copy Number Variations, Gene Amplification, Genetic Loci, Hemangiosarcoma, Lymphedema.
- Adult, Aged, Aged, 80 and over, Chromosome Deletion, Chronic Disease, Female, Homozygote, Humans, In Situ Hybridization, Fluorescence, Male, Middle Aged.

Abstract

Angiosarcomas (AS) are rare vascular malignancies that arise either de novo as primary tumors or secondary to irradiation or chronic lymphedema. The cytogenetics of angiosarcomas are poorly characterized. We applied array-comparative genomic hybridization as a screening method to identify recurrent alterations in 22 cases. Recurrent genetic alterations were identified only in secondary but not in primary AS. The most frequent recurrent alterations were high level amplifications on chromosome 8q24.21 (50%), followed by 10p12.33 (33%) and 5q35.3 (11%). Fluorescence in situ hybridization analysis in 28 primary and 33 secondary angiosarcomas (31 tumors secondary to irradiation, 2 tumors secondary to chronic lymphedema) confirmed high level amplification of MYC on chromosome 8q24.21 as a recurrent genetic alteration found exclusively in 55% of AS secondary to irradiation or chronic lymphedema, but not in primary AS. Amplification of MYC did not predispose to high grade morphology or increased cell turnover. In conclusion, despite their identical morphology, secondary AS are genetically different from primary AS and are characterized by a high frequency of high level amplifications of MYC. This finding may have implications both for the diagnosis and treatment of these tumors.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797867

DOI: 10.2353/ajpath.2010.090637
PubMed: 20008140
PubMed Central: 2797867

Affiliations:

Links to Exploration step

PMC:2797867

Le document en format XML

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 High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema</title>
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 High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema</title>
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<author><name sortKey="Hohenberger, Peter" sort="Hohenberger, Peter" uniqKey="Hohenberger P" first="Peter" last="Hohenberger">Peter Hohenberger</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Surgery, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg</wicri:regionArea>
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<wicri:noRegion>University of Heidelberg</wicri:noRegion>
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<author><name sortKey="Mossinger, Katharina" sort="Mossinger, Katharina" uniqKey="Mossinger K" first="Katharina" last="Mössinger">Katharina Mössinger</name>
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<wicri:regionArea>Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg</wicri:regionArea>
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<author><name sortKey="Kuffer, Stefan" sort="Kuffer, Stefan" uniqKey="Kuffer S" first="Stefan" last="Küffer">Stefan Küffer</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg</wicri:regionArea>
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<author><name sortKey="Sauer, Christian" sort="Sauer, Christian" uniqKey="Sauer C" first="Christian" last="Sauer">Christian Sauer</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg</wicri:regionArea>
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<author><name sortKey="Belharazem, Djeda" sort="Belharazem, Djeda" uniqKey="Belharazem D" first="Djeda" last="Belharazem">Djeda Belharazem</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg</wicri:regionArea>
<wicri:noRegion>University of Heidelberg</wicri:noRegion>
<wicri:noRegion>University of Heidelberg</wicri:noRegion>
<wicri:noRegion>University of Heidelberg</wicri:noRegion>
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<author><name sortKey="Zettl, Andreas" sort="Zettl, Andreas" uniqKey="Zettl A" first="Andreas" last="Zettl">Andreas Zettl</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">Pathology Viollier, Basle, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Pathology Viollier, Basle</wicri:regionArea>
<wicri:noRegion>Basle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Coindre, Jean Michel" sort="Coindre, Jean Michel" uniqKey="Coindre J" first="Jean-Michel" last="Coindre">Jean-Michel Coindre</name>
<affiliation wicri:level="3"><nlm:aff id="aff5">Department of Pathology and INSERM U916, Institut Bergonié and Laboratory of Pathology, University Victor Ségalen, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Pathology and INSERM U916, Institut Bergonié and Laboratory of Pathology, University Victor Ségalen, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hallermann, Christian" sort="Hallermann, Christian" uniqKey="Hallermann C" first="Christian" last="Hallermann">Christian Hallermann</name>
<affiliation wicri:level="3"><nlm:aff id="aff6">Department of Dermatology, Fachklinik Hornheide, Münster, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Dermatology, Fachklinik Hornheide, Münster</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hartmann, Jorg Thomas" sort="Hartmann, Jorg Thomas" uniqKey="Hartmann J" first="Jörg Thomas" last="Hartmann">Jörg Thomas Hartmann</name>
<affiliation wicri:level="3"><nlm:aff id="aff7">Department of Medical Oncology, Medical Center II, Eberhard-Karls-University, Tuebingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Medical Oncology, Medical Center II, Eberhard-Karls-University, Tuebingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Katenkamp, Detlef" sort="Katenkamp, Detlef" uniqKey="Katenkamp D" first="Detlef" last="Katenkamp">Detlef Katenkamp</name>
<affiliation wicri:level="1"><nlm:aff id="aff8">Institute of Pathology, University of Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Pathology, University of Jena</wicri:regionArea>
<wicri:noRegion>University of Jena</wicri:noRegion>
<wicri:noRegion>University of Jena</wicri:noRegion>
<wicri:noRegion>University of Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Katenkamp, Kathrin" sort="Katenkamp, Kathrin" uniqKey="Katenkamp K" first="Kathrin" last="Katenkamp">Kathrin Katenkamp</name>
<affiliation wicri:level="1"><nlm:aff id="aff8">Institute of Pathology, University of Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Pathology, University of Jena</wicri:regionArea>
<wicri:noRegion>University of Jena</wicri:noRegion>
<wicri:noRegion>University of Jena</wicri:noRegion>
<wicri:noRegion>University of Jena</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schoffski, Patrick" sort="Schoffski, Patrick" uniqKey="Schoffski P" first="Patrick" last="Schöffski">Patrick Schöffski</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Catholic University Leuven, Leuven, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Catholic University Leuven, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sciot, Raf" sort="Sciot, Raf" uniqKey="Sciot R" first="Raf" last="Sciot">Raf Sciot</name>
<affiliation wicri:level="1"><nlm:aff id="aff10">Laboratory of Morphology and Molecular Pathology, Department of Pathology, University Hospital, Catholic University of Leuven, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory of Morphology and Molecular Pathology, Department of Pathology, University Hospital, Catholic University of Leuven</wicri:regionArea>
<wicri:noRegion>Catholic University of Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wozniak, Agnieszka" sort="Wozniak, Agnieszka" uniqKey="Wozniak A" first="Agnieszka" last="Wozniak">Agnieszka Wozniak</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Catholic University Leuven, Leuven, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Catholic University Leuven, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lichter, Peter" sort="Lichter, Peter" uniqKey="Lichter P" first="Peter" last="Lichter">Peter Lichter</name>
<affiliation wicri:level="3"><nlm:aff id="aff3">German Cancer Research Center (DKFZ), Division of Molecular Genetics, Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Cancer Research Center (DKFZ), Division of Molecular Genetics, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marx, Alexander" sort="Marx, Alexander" uniqKey="Marx A" first="Alexander" last="Marx">Alexander Marx</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg</wicri:regionArea>
<wicri:noRegion>University of Heidelberg</wicri:noRegion>
<wicri:noRegion>University of Heidelberg</wicri:noRegion>
<wicri:noRegion>University of Heidelberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Strobel, Philipp" sort="Strobel, Philipp" uniqKey="Strobel P" first="Philipp" last="Ströbel">Philipp Ströbel</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Pathology, Division of Surgical Oncology and Thoracic Surgery, University Medical Centre Mannheim, University of Heidelberg</wicri:regionArea>
<wicri:noRegion>University of Heidelberg</wicri:noRegion>
<wicri:noRegion>University of Heidelberg</wicri:noRegion>
<wicri:noRegion>University of Heidelberg</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">The American Journal of Pathology</title>
<idno type="ISSN">0002-9440</idno>
<idno type="eISSN">1525-2191</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Chromosome Deletion</term>
<term>Chronic Disease</term>
<term>DNA Copy Number Variations (genetics)</term>
<term>Female</term>
<term>Gene Amplification (genetics)</term>
<term>Genetic Loci (genetics)</term>
<term>Hemangiosarcoma (etiology)</term>
<term>Hemangiosarcoma (genetics)</term>
<term>Homozygote</term>
<term>Humans</term>
<term>In Situ Hybridization, Fluorescence</term>
<term>Lymphedema (complications)</term>
<term>Lymphedema (genetics)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Proto-Oncogene Proteins c-myc (genetics)</term>
<term>Radiotherapy (adverse effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Amplification de gène (génétique)</term>
<term>Délétion de segment de chromosome</term>
<term>Femelle</term>
<term>Homozygote</term>
<term>Humains</term>
<term>Hémangiosarcome (génétique)</term>
<term>Hémangiosarcome (étiologie)</term>
<term>Locus génétiques (génétique)</term>
<term>Lymphoedème ()</term>
<term>Lymphoedème (génétique)</term>
<term>Maladie chronique</term>
<term>Mâle</term>
<term>Protéines proto-oncogènes c-myc (génétique)</term>
<term>Radiothérapie (effets indésirables)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Technique FISH</term>
<term>Variations de nombre de copies de segment d'ADN (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Proto-Oncogene Proteins c-myc</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Radiotherapy</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Radiothérapie</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hemangiosarcoma</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>DNA Copy Number Variations</term>
<term>Gene Amplification</term>
<term>Genetic Loci</term>
<term>Hemangiosarcoma</term>
<term>Lymphedema</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Amplification de gène</term>
<term>Hémangiosarcome</term>
<term>Locus génétiques</term>
<term>Lymphoedème</term>
<term>Protéines proto-oncogènes c-myc</term>
<term>Variations de nombre de copies de segment d'ADN</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Hémangiosarcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Chromosome Deletion</term>
<term>Chronic Disease</term>
<term>Female</term>
<term>Homozygote</term>
<term>Humans</term>
<term>In Situ Hybridization, Fluorescence</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Délétion de segment de chromosome</term>
<term>Femelle</term>
<term>Homozygote</term>
<term>Humains</term>
<term>Lymphoedème</term>
<term>Maladie chronique</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Technique FISH</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Angiosarcomas (AS) are rare vascular malignancies that arise either <bold><italic>de novo</italic>
</bold>
 as primary tumors or secondary to irradiation or chronic lymphedema. The cytogenetics of angiosarcomas are poorly characterized. We applied array-comparative genomic hybridization as a screening method to identify recurrent alterations in 22 cases. Recurrent genetic alterations were identified only in secondary but not in primary AS. The most frequent recurrent alterations were high level amplifications on chromosome 8q24.21 (50%), followed by 10p12.33 (33%) and 5q35.3 (11%). Fluorescence in situ hybridization analysis in 28 primary and 33 secondary angiosarcomas (31 tumors secondary to irradiation, 2 tumors secondary to chronic lymphedema) confirmed high level amplification of <bold><italic>MYC</italic>
</bold>
 on chromosome 8q24.21 as a recurrent genetic alteration found exclusively in 55% of AS secondary to irradiation or chronic lymphedema, but not in primary AS. Amplification of <bold><italic>MYC</italic>
</bold>
 did not predispose to high grade morphology or increased cell turnover. In conclusion, despite their identical morphology, secondary AS are genetically different from primary AS and are characterized by a high frequency of high level amplifications of <bold><italic>MYC</italic>
</bold>
. This finding may have implications both for the diagnosis and treatment of these tumors.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Belgique</li>
<li>France</li>
<li>Suisse</li>
</country>
<region><li>Aquitaine</li>
<li>Bade-Wurtemberg</li>
<li>District de Karlsruhe</li>
<li>District de Münster</li>
<li>District de Tübingen</li>
<li>Nouvelle-Aquitaine</li>
<li>Rhénanie-du-Nord-Westphalie</li>
</region>
<settlement><li>Bordeaux</li>
<li>Heidelberg</li>
<li>Münster</li>
<li>Tübingen</li>
</settlement>
</list>
<tree><country name="Allemagne"><noRegion><name sortKey="Manner, Johanna" sort="Manner, Johanna" uniqKey="Manner J" first="Johanna" last="Manner">Johanna Manner</name>
</noRegion>
<name sortKey="Belharazem, Djeda" sort="Belharazem, Djeda" uniqKey="Belharazem D" first="Djeda" last="Belharazem">Djeda Belharazem</name>
<name sortKey="Hallermann, Christian" sort="Hallermann, Christian" uniqKey="Hallermann C" first="Christian" last="Hallermann">Christian Hallermann</name>
<name sortKey="Hartmann, Jorg Thomas" sort="Hartmann, Jorg Thomas" uniqKey="Hartmann J" first="Jörg Thomas" last="Hartmann">Jörg Thomas Hartmann</name>
<name sortKey="Hohenberger, Peter" sort="Hohenberger, Peter" uniqKey="Hohenberger P" first="Peter" last="Hohenberger">Peter Hohenberger</name>
<name sortKey="Katenkamp, Detlef" sort="Katenkamp, Detlef" uniqKey="Katenkamp D" first="Detlef" last="Katenkamp">Detlef Katenkamp</name>
<name sortKey="Katenkamp, Kathrin" sort="Katenkamp, Kathrin" uniqKey="Katenkamp K" first="Kathrin" last="Katenkamp">Kathrin Katenkamp</name>
<name sortKey="Kuffer, Stefan" sort="Kuffer, Stefan" uniqKey="Kuffer S" first="Stefan" last="Küffer">Stefan Küffer</name>
<name sortKey="Lichter, Peter" sort="Lichter, Peter" uniqKey="Lichter P" first="Peter" last="Lichter">Peter Lichter</name>
<name sortKey="Marx, Alexander" sort="Marx, Alexander" uniqKey="Marx A" first="Alexander" last="Marx">Alexander Marx</name>
<name sortKey="Mossinger, Katharina" sort="Mossinger, Katharina" uniqKey="Mossinger K" first="Katharina" last="Mössinger">Katharina Mössinger</name>
<name sortKey="Radlwimmer, Bernhard" sort="Radlwimmer, Bernhard" uniqKey="Radlwimmer B" first="Bernhard" last="Radlwimmer">Bernhard Radlwimmer</name>
<name sortKey="Sauer, Christian" sort="Sauer, Christian" uniqKey="Sauer C" first="Christian" last="Sauer">Christian Sauer</name>
<name sortKey="Strobel, Philipp" sort="Strobel, Philipp" uniqKey="Strobel P" first="Philipp" last="Ströbel">Philipp Ströbel</name>
</country>
<country name="Suisse"><noRegion><name sortKey="Zettl, Andreas" sort="Zettl, Andreas" uniqKey="Zettl A" first="Andreas" last="Zettl">Andreas Zettl</name>
</noRegion>
</country>
<country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Coindre, Jean Michel" sort="Coindre, Jean Michel" uniqKey="Coindre J" first="Jean-Michel" last="Coindre">Jean-Michel Coindre</name>
</region>
</country>
<country name="Belgique"><noRegion><name sortKey="Schoffski, Patrick" sort="Schoffski, Patrick" uniqKey="Schoffski P" first="Patrick" last="Schöffski">Patrick Schöffski</name>
</noRegion>
<name sortKey="Sciot, Raf" sort="Sciot, Raf" uniqKey="Sciot R" first="Raf" last="Sciot">Raf Sciot</name>
<name sortKey="Wozniak, Agnieszka" sort="Wozniak, Agnieszka" uniqKey="Wozniak A" first="Agnieszka" last="Wozniak">Agnieszka Wozniak</name>
</country>
</tree>
</affiliations>
</record>

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MYC High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema

MYC High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema

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